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ליגנדים עבור דימוי של עצבוב הלב
专利权人:
LANTHEUS MEDICAL IMAGING INC.
发明人:
申请号:
IL22439613
公开号:
IL224396A
申请日:
2013.01.24
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18 F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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