Embodiments herein disclose a design method for a biomedical signal conditioning circuit. The method includes computing a flicker noise power over a bandwidth. Further, the method includes finding a quantitative relation between the flicker noise power and a total input area. Further, the method includes computing a thermal noise power based on the bandwidth, a thermal noise co-efficient and a transconductance. Further, the method includes finding a quantitative relation between a total integrated noise power, a bias current and a total input device area. The total integrated noise power is computed based on the flicker noise power and the thermal noise power. Further, the method includes identifying a relationship between the total integrated noise power, the bias current and the total input device area. FIG. 1