Method for producing thiabenzoazulene propionic acid derivatives

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专利权人:

日本臓器製薬株式会社

发明人:

東浦 邦彦,伊藤 泰三,荻野 尚志,長谷川 泰介

申请号：

JP2011524773

公开号：

JP5606440B2

申请日:

2010.07.26

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Disclosed is a process for producing a thiabenzoazulene-propionic acid derivative which is useful as an active ingredient of an antihistaminic agent or the like. According to the producing process of the present invention, it is possible to produce a thiabenzoazulene-propionic acid derivativewhere the 2-position of the thiabenzoazulene skeleton is substituted with propionic acid. The thiabenzoazulene propionic-acid derivative thus synthesized has excellent antagonistic action to histamine H1 receptor and low intracerebral transmigration and, therefore, is useful as an active ingredient of the pharmaceutical composition such as an antihistaminic agent.

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中国工程科技知识中心

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