Infusion systems according to the present invention provide a medical fluid infusion system operable at a relatively wide range of flow rates while simultaneously maintaining a high degree of accuracy and predictability through employing specific flow path architecture, flow path dimensional ranges, and pump control parameters, such as voltage, frequency, voltage rise time, pump size and quantity, and controlled restriction of the fluid flow path. Automatic recognition of restrictive elements is employed to facilitate the ease of use of different restrictive elements with a single infusion system and improve patient safety.