A method for insertion maintenance and removal of urethral catheters in mammals including humans includes steps for preventing or reducing the incidence of catheter associated urinary tract infections. In addition to sterile procedures currently practiced or as may be practiced in the future in connection with catheter use the method includes the steps of applying an antiseptic zwitterionic and acidic skincare solution capable of preserving the stratum corneum to the perineum meatus and contiguous mucosa surrounding the insertion site before insertion after insertion periodically during the period of indwelling in connection with any incidence of incontinence and optionally before and after removal of the catheter. Application of the solution optionally is continued after catheter removal on a periodic basis until the threat of an infection associated with catheter use has passed typically at least about five (5) to seven (7) days and up to thirty (30) days. The solution pH is desirably from about 4.4 to 5.5.
