ENDO, Atsushi,YU, Robert T.,FANG, Francis,CHOI, Hyeong Wook,SHAN, Mingde
申请号:
PH12018500265
公开号:
PH12018500265A1
申请日:
2018.02.05
申请国别(地区):
PH
年份:
2018
代理人:
摘要:
We provide diastereomerically pure or substantially diastereomerically pure activated phosphoramidochloridate morpholino nucleosides, methods of their preparation, and methods of their use in stereospecific coupling for stereospecific synthesis of diastereomerically pure phosphorodiamidate morpholino oligomers (PMOs).