DAL FARRA, CLAUDE,DOMLOGE, NOUHA,BOTTO, JEAN-MARIE
申请号：
ES09804288
公开号：
ES2534513T3
申请日:
2009.12.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Peptide derived from human HMG-CoA reductase, of general formula (I) R1- (AA) n-X1-Gly-Lys-X2- (AA) p-R2 Where X1 is lysine or arginine or any amino acid , X2 is serine or threonine, AA represents any one amino acid, or one of its derivatives, and p and p are whole numbers between 0 and 4, R1 represents the primary amine function of the N-terminal amino acid, free or substituted by a protective group which may be selected from an acetyl group, a benzoyl group, a tosyl group or a benzyloxycarbonyl group, R2 represents the hydroxy group of the carboxyl function of the C-terminal amino acid, free or substituted by a protecting group that can be selected from an alkyl chain C1 to C20, or an NH2, NHY or NYY group with Y representing a C1 to C4 alkyl chain. characterized in that the peptide is selected from the following sequences: (SEQ ID No. 1) Glu-Gly-Lys-Gly-Lys-Ser-Val-Val-Cys-Glu (SEQ ID No. 2) Glu-Gly-Lys- Gly-Lys-Ser-Val-Val (SEQ ID No. 3) Asp-Gly-Lys-Gly-Lys-Thr (SEQ ID No. 4) Arg-Gly-Lys-Ser (SEQ ID No. 5) Arg- Gly-Lys-Ser-NH2 (SEQ ID No. 6) Arg-Gly-Lys-Thr (SEQ ID No. 7) Arg-Gly-Lys-Thr-NH2 (SEQ ID No. 8) Lys-Gly-Lys- Ser (SEQ ID No. 9) Lys-Gly-Lys-Ser-NH2 (SEQ ID No. 10) Gly-Lys-Ser-NH2.Peptido derivado de la HMG-CoA reductasa humana, de formula general (I) R1-(AA)n-X1-Gly-Lys-X2-(AA)p-R2 En la que X1 es la lisina o la arginina o cualquier aminoacido, X2 es la serina o la treonina, AA representa un aminoacido cualquiera, o uno de sus derivados, ynyp son numeros enteros comprendidos entre 0 y 4, R1 representa la funcion amina primaria del aminoacido N-terminal, libre o sustituido por un grupo protector que se puede seleccionar de un grupo acetilo, un grupo benzoilo, un grupo tosilo o un grupo benciloxicarbonilo, R2 representa el grupo hidroxilo de la funcion carboxilo del aminoacido C- terminal, libre o sustituido por un grupo protector que puede seleccionarse de una cadena alquilo de C1 a C20, o un grupo NH2, NHY o NYY con Y representando una cadena alquilo de
