Atilgan Yilmaz;Justin R. Fallon;Alison R. Amenta;Michelle Dechene;Beth A. McKechnie
发明人:
Justin R. Fallon,Alison R. Amenta,Beth A. McKechnie,Michelle Dechene,Atilgan Yilmaz
申请号:
US15976225
公开号:
US20180327469A1
申请日:
2018.05.10
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present disclosure provides compositions and methods for treating diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.