ERNST BEAT,HERRENDORFF RUBEN,STECK ANDREAS,YANG FAN
申请号：
IN201617029838
公开号：
IN201617029838A
申请日:
2016.09.01
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer 1 (HNK 1) epitope that bind to anti MAG (myelin associated glycoprotein) IgM antibodies and their use in diagnosis as well as for the treatment of anti MAG neuropathy. In particular the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl heteroaryl arylcarbonyl or heteroarylmethyl and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II) wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.
