Ernst, Beat,Herrendorff, Ruben,Steck, Andreas,Yang, Fan
申请号：
AU2019271964
公开号：
AU2019271964A1
申请日:
2019.11.27
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019271964A120191219.pdf#####ABSTRACT The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM 5 antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (1) and (11) COONa HO COONa H HO -S O1 0 OZ H - - 0 0 O NaO3SO OOZ HO Z OH OH (1) and OH OH (1) 10 wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (1) and/or formula (11), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.
