The invention relates to a method for filling and rinsing a set of blood lines, comprising a pump segment for a blood pump, an arterial line connected to an input of a dialysis machine and a venous line connected to the output of a dialysis machine, by means of a substitute line. Said method comprises the steps of connecting the arterial line to the venous line and connecting both lines to a rinse port, connecting the substitute line to a substitute port, opening the rinse port, filling the arterial and venous line, rinsing the arterial and venous line, closing the rinse port, circulating the substitute in the circuit of arterial line, dialysis machine, and venous line by means of the blood pump, characterised in that the filling and/or rinsing of the venous and the arterial line occurs simultaneously wherein substitute is introduced from the substitute line. The invention further relates to a set of blood lines.