AHRENS, BIANCA,BAXI, SANGITA M.,BERGQVIST, SIMON PAUL,DOYONNAS, REGIS,DUFIELD, ROBERT LEE,ELLIOTT, MARK WILLIAM,FISHER, TIMOTHY SCOTT,JEROME, RICHARD MICHAEL,JONES, HEATHER LAURANCE,KAMPERSCHROER, CRI
申请号：
PE0004042013
公开号：
PE14652013A1
申请日:
2011.08.26
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to binding Molecules 4-1bb Antibodies are IgG and include: (a) H - SEC ID no: 29 CDR1, CDR2 (b) H - SEC ID no: 30, (c) H - CDr3 SEC ID no: 31 (d) L - CDR1 SEC ID no: 34), and L - CDR2 of SEC ID no: 35, f) L - CDr3 SEC ID no: 36. These molecules Exhibit a region of 43 sec id no: VH and vl region id no: 45 sec.These molecules include a SEC ID no: heavy chain and a light chain of 44 sec id no: 46 in the case of the rest of c-terminal lysine of sec id no: 44 is absent. In addition to such a Pharmaceutical composition.SE REFIERE A MOLECULAS DE UNION A 4-1BB QUE SON ANTICUERPOS IgG2 Y QUE COMPRENDEN: A) H-CDR1 DE SEC ID NO: 29, B) H-CDR2 DE SEC ID NO: 30, C) H-CDR3 DE SEC ID NO: 31, D) L-CDR1 DE SEC ID NO: 34, E) L-CDR2 DE SEC ID NO: 35, F) L-CDR3 DE SEC ID NO: 36. DICHAS MOLECULAS PRESENTAN UNA REGION VH DE SEC ID NO: 43 Y UNA REGION VL DE SEC ID NO: 45. DICHAS MOLECULAS COMPRENDEN UNA CADENA PESADA DE SEC ID NO: 44 Y UNA CADENA LIGERA DE SEC ID NO: 46 EN EL CASO DE QUE EL RESTO DE LISINA C-TERMINAL DE SEC ID NO: 44 ESTE AUSENTE. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA.
