Zhu, Lei,Cardarelli, Josephine M.,Albanese, Jenny,Passmore, David B.
申请号：
AU2006214032
公开号：
AU2006214032B2
申请日:
2006.02.17
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.
