КОЛКА Джерард Р. (US),КЛЕТЗИН Рольф Ф. (US),ТАНИС Стивен П. (US),ЛАРСЕН Скотт Д. (US)
申请号：
RU2012129971/15
公开号：
RU2012129971A
申请日:
2010.12.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for treating or delaying the manifestation of obesity comprising administering to a patient a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:each of R1 and R4 It is independently selected from H, halo, aliphatic, and alkoxy radicals, where the aliphatic radical or alkoxy optionally substituted with 1-3 haloR 2 It represents HR2 It represents H, halo, hydroxy, or optionally substituted aliphatic radical, -O-acyl, -O-aroyl, -O-heteroaroyl, -O (SO2) NH2, -O-CH (Rm) OC (O) Rn, -O-CH (Rm) OP (O) (ORn)2, -OP (O) (ORn)2 or Where each Rm It is independently optionally substituted C16alkyl, each Rn It is independently C1-12alkyl, C3-8cycloalkyl or phenyl, each of which is optionally substituted, orR2 and R 2 together form oxoR3 It represents H andRing A is phenyl, pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, each of which is substituted with R1-group and R4-group in any chemically possible position on the ring A.2. The method of claim 1 wherein R4 It represents H, methyl, methoxy, ethyl, ethoxy, -O-isopropyl, -CF3, -OCHF2 or -OCF3.3. The method of claim 1 or 2, wherein ring A represents phenyl which is substituted by R1- And R4-groups in any chemically possible position in the ring A.4. A method according to claim 1 or 2, wherein Ring A is pyridin-2-yl or pyridin-3-yl, any of which is substituted with R1- And R4-groups in any chemically possible position in the ring A.5. The method of claim 3, wherein ring A is phenyl and one of R1 or R4 attached to the para- or meta-position of the ring A.6. The method of claim 5, wherein Ring A is phenyl and one of R1 or R4 attached to the meta-position of the ring A.7. The method of claim 4, wherein Ring A is pyridin-2-yl, and one of R1 or R4 attached to the 5 position of the ring.8. The method of claim 4, wherein Ring A is pyridin-3-yl, and one of R1 or R4 attached to the 6 position of the ring.9. The method of claim 5 wherein R1 attached to the para- or meta-position of the ring A.10. The method
