Peter Joseph Alff;Claudio Bertuccioli;Mark Andrew Yondola;Christopher Patrick Marshall
发明人:
Christopher Patrick Marshall,Peter Joseph Alff,Claudio Bertuccioli,Mark Andrew Yondola
申请号：
US14450236
公开号：
US09393297B2
申请日:
2014.08.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.
