DR. P. KALIRAJ,MADHUMATHI. J,G. ANUGRAHA,PRINCE.R.PRABHU
申请号：
IN1367/CHE/2011
公开号：
IN278637B
申请日:
2011.04.20
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides methods and compositions for eliciting humoral immunity against lymphatic filariasis. In particular, the present invention discloses two peptide immunogens comprising immunodominant B epitopes from the filarial Secretory protein Abundant Larval Transcript (ALT-2) of Brugia Malayi. They were identified by monoclonal antibodies which were developed against purified recombinant ALT-2. Eight different peptides from ALT-2 protein were screened for dominant B epitopes and two peptide regions were identified. The peptides were immunized in BALB/ c (H-2d) mice and the antibody response was measured in terms of peak titers by ELISA. These two peptide immunogens induces a strong humoral response in mice models equivalent to recombinant ALT-2 whole protein. The two synthetic peptide immunogens is a highly immunogenic peptide vaccine for lymphatic filariasis.
