Methods of reprocessing physiological sensors may include applying heat to a physiological sensor so as to efficiently remove adhesives, adhesive layers, and/or other disposable components of the sensor. Heat may be applied to the physiological sensor efficiently via a medium, such as an aqueous solution (for example, water). Reusable components of the physiological sensor may then be reassembled with new disposable components and/or adhesives to produce a reprocessed sensor. The methods may further include testing and/or replacement of various reusable sensor components, testing of the reprocessed sensor, cleaning of the reprocessed sensor and/or sensor components, and/or sterilization of the reprocessed sensor, among other steps.