CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE AND METHODS OF USING THE SAME
PARATEK PHARMACEUTICALS, INC.;ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED
发明人:
CATHERINE, COULTER,SEAN M., JOHNSTON,FARZANEH, SEYEDI
申请号：
TR201911086
公开号：
TR201911086T4
申请日:
2012.05.14
申请国别(地区):
TR
年份:
2019
代理人:
摘要：
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene- 2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.Gelişmiş stabiliteye sahip (4S,4aS,5aR,12aS)-4-dimetilamino-3,10,12,12a-tetrahidroksi-7-[(metoksi(metil)amino)-metil]-1,11-diokso-1,4,4a,5,5a,6,11,12a-oktahidro-naftasen-2-karboksilik asit amidin bir kristalli mono hidroklorür tuzu tarif edilmektedir. Ek olarak, gelişmiş stabiliteye sahip (4S,4aS,5aR,12aS)-4-dimetilamino-3,10,12,12a-tetrahidroksi-7-[(metoksi(metil)amino)-metil]-1,11-diokso-1,4,4a,5,5a,6,11,12a-oktahidro-naftasen-2-karboksilik asit amidin bir kristalli mono mezilat tuzu ve kristalli mono sülfat tuzu tarif edilmektedir. Kristalli tuzların uygulanmasını içeren, inflamatuvar cilt bozukluklarının ve bakteriyel enfeksiyonların tedavisine yönelik kristalli tuzları ve yöntemleri içeren bir farmasötik bileşim tarif edilmektedir.
