A method for processing a cosmetic product with high hydrostatic pressures by applying a pressure P to the cosmetic product, with a continuous or cyclic application mode MA. The method is performed using at least one, and preferably all, of the following parameters: total application time t of pressure P of between 2 and 60 minutes, a pressure P of between 200 MPa and 600 MPa, a pressure application rate, for a compression VA, of between 1 and 5 QMPa/s, a decompression rate VAD of between 1 and 50 MPa/s, when the application mode is cyclic, a latency time tlat applied before the first cycle and/or between certain cycles and/or between each cycle, and an initial temperature of between −10° C. and 40° C. Also, the cosmetic product obtained and a device for implementing. The method can be used to deactivate microorganism(s) in pharmaceutical product or to modify the texture of the same.