CHENG, Seng, H.,SHIHABUDDIN, Lamya,SARDI, Sergio, Pablo
申请号：
HK18103748.9
公开号：
HK1244217A
申请日:
2018.03.19
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
This disclosure relates to a method of treating a proteinopathy in a subject, the method comprising administering to the subject an effective amount of a quinuclidine compound. The disclosure also relates to a method of reducing, reversing or preventing the accumulation of protein aggregates in tissue of a subject diagnosed as having a proteinopathy, or being at risk of developing a proteinopathy, the method comprising administering to the subject an effective amount of a quinuclidine compound. Also disclosed is a pharmaceutical composition comprising a quinuclidine compound for use in said methods. The proteinopathy may be a synucleinopathy or a tauopathy, such as Parkinson's disease, Alzheimer's disease or dementia with Lewy bodies.
