CHENG, SENG H.,SHIHABUDDIN, LAMYA,SARDI, SERGIO PABLO
申请号：
CA2978883
公开号：
CA2978883A1
申请日:
2016.03.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This disclosure relates to a method of treating a proteinopathy in a subject, the method comprising administering to the subject an effective amount of a quinuclidine compound. The disclosure also relates to a method of reducing, reversing or preventing the accumulation of protein aggregates in tissue of a subject diagnosed as having a proteinopathy, or being at risk of developing a proteinopathy, the method comprising administering to the subject an effective amount of a quinuclidine compound. Also disclosed is a pharmaceutical composition comprising a quinuclidine compound for use in said methods. The proteinopathy may be a synucleinopathy or a tauopathy, such as Parkinson's disease, Alzheimer's disease or dementia with Lewy bodies.
