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Identification of a 5-Gene Expression Signature Predicting Clinical Outcome of Patients with Brain Tumors
专利权人:
Antonio Iavarone
发明人:
Antonio Iavarone,Anna Lasorella
申请号:
US15691064
公开号:
US20180030546A1
申请日:
2017.08.30
申请国别(地区):
US
年份:
2018
代理人:
摘要:
High-grade gliomas are the most common brain tumors in humans and are essentially incurable. The defining hallmark of these high-grade gliomas is the presence within the tumor mass of highly tumorigenic cellular subpopulations that fuel tumor aggressiveness. Identification of the molecular mechanisms remains elusive. Therefore, there is a need for diagnostic markers to accurately determine the type of glioma and appropriate treatment. Gene delivery vehicles are provided that comprise an oncogene, IRES-Cre-ER cassette and a gene encoding an oligonucleotide that inhibits p53 including shp53. Methods are also provided for determining a diagnosis and for treatment of non-aggressive and aggressive gliomas.
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