The present invention relates to a kind of compositions, and it includes a kind of mixtures, including, optionally, by a effective amount of colostrum and at least one pharmaceutical grade additive, the composition is used to treat the disease of urinary system. Particularly, the present invention relates to for treating the more preferable interstitial cystitis of synthetic described in chronic pelvic pain, especially cystitis. The present invention relates to a kind of compositions, and it includes a kind of mixtures, including, or alternatively, by following components: a kind of) colostrum The chondroitin sulfate of step b) or its salt, optionally, c, salicin, the composition further include at least one pharmacy or food grade additives. The present invention relates to a kind of medical devices comprising the composition.