Bett, Andrew J.,Dodson, Elizabeth Chen,Kinney, Gene,Viola, Kirsten L.,Chang, Lei,Lambert, Mary P.,An, Zhiqiang,Shughrue, Paul,Breese, Robert,Klein, William,Strohl, William R.,Liang, Xiaoping,Acton, Pa
申请号：
AU2012232964
公开号：
AU2012232964A1
申请日:
2012.09.28
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012232964A120121018.pdf#####ABSTRACT The present invention relates to antibodies that differentially recognize multi-dimensional conformation of 5 Ap-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimers Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimers Disease. The present antibodies also block 10 binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid p 1-42. C) 80~-X 70 C/) 60 w b 50T 40 Z 30-M 00 TE M 20z1020 TEAt ( qMT(X)04
