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Thioacetate compounds, compositions and methods of use
专利权人:
ARDEA BIOSCIENCES; INC.
发明人:
OUK, SAMEDY,GUNIC, ESMIR,VERNIER, JEAN-MICHEL
申请号:
ES13198843
公开号:
ES2551114T3
申请日:
2011.06.15
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of Formula (I-K): ** Formula ** in which: X1 is CH; X2 is N; X3 is CH; X4 is CH; Ra and Rb are both CH3; M is C1-3 alkyl; Y1 is CR1; Y2 is CR2; R1 is H, CF3, CH3, OCH3, F or Cl; R2 is H, methyl, ethyl, propyl, isopropyl, tert-butyl, cyclopropyl, cyclobutyl, CF3, OH, OCH3, ethoxy, SH, SCH3, SCH2CH3, CH2OH, C (CH3) 2OH, Cl, F, CN, COOH, COOR2 ', CONH2, CONHR2' or SO2NH2; where R2 'is H or C1-3 alkyl; n is 1, 2, 3 or 4; R5 is independently selected from H, methyl, ethyl, propyl, isopropyl, tert-butyl, cyclopropyl, cyclobutyl, CF3, OH, OCH3, ethoxy, SH, SCH3, SCH2CH3, CH2OH, C (CH3) 2OH, Cl, F, CN , COOH, COOR5 ', CONH2, CONHR5' or SO2NH2; where R5 'is H or C1-3 alkyl.Un compuesto de Fórmula (I-K):**Fórmula** en el que: X1 es CH; X2 es N; X3 es CH; X4 es CH; Ra y Rb son ambos CH3; M es alquilo de C1-3; Y1 es CR1; Y2 es CR2; R1 es H, CF3, CH3, OCH3, F o Cl; R2 es H, metilo, etilo, propilo, isopropilo, terc-butilo, ciclopropilo, ciclobutilo, CF3, OH, OCH3, etoxi, SH, SCH3, SCH2CH3, CH2OH, C(CH3)2OH, Cl, F, CN, COOH, COOR2', CONH2, CONHR2' o SO2NH2; donde R2' es H o alquilo de C1-3; n es 1, 2, 3 o 4; R5 se selecciona independientemente entre H, metilo, etilo, propilo, isopropilo, terc-butilo, ciclopropilo, ciclobutilo, CF3, OH, OCH3, etoxi, SH, SCH3, SCH2CH3, CH2OH, C(CH3)2OH, Cl, F, CN, COOH, COOR5', CONH2, CONHR5' o SO2NH2; donde R5' es H o alquilo de C1-3.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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