The invention concerns a combination comprising ferroquine, in free base, salt, hydrate or solvate form, and an artemisinine derivative. The invention also concerns a pharmaceutical composition comprising ferroquine, in the form of one of its pharmaceutically acceptable salts, ferroquine hydrate or solvate, and at least one artemisinine derivative. The invention further concerns the use of such a combination for preparing a medicine for treating or preventing malaria. Finally, the invention concerns a kit for treating or preventing malaria.