THE INVENTION RELATES TO A COMBINATION WHICH COMPRISES FERROQUINE IN THE FORM OF A FREE BASE, OF A SALT, OF A HYDRATE OR OF A SOLVATE, AND AN ARTEMISININ DERIVATIVE. THE INVENTION ALSO RELATES TO A PHARMACEUTICAL COMPOSITION COMPRISING FERROQUINE, IN THE FORM OF ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS OR OF A HYDRATE OR A SOLVATE OF FERROQUINE, AND AT LEAST ONE ARTEMISININ DERIVATIVE. THE INVENTION ALSO RELATES TO THE USE OF SUCH A COMBINATION FOR PREPARING A MEDICINAL PRODUCT FOR USE IN THE TREATMENT OR PREVENTION OF MALARIA. FINALLY, THE INVENTION RELATES TO A KIT FOR THE TREATMENT OR PREVENTION OF MALARIA.