A method for producing a dental mill blank, characterized in that the method includes contacting an inorganic filler molded article produced by subjecting an inorganic filler to press molding and a polymerizable monomer-containing composition, and allowing the polymerizable monomer to polymerize and cure. When the method of the present invention is used, a dental mill blank having a high inorganic powder content and excellent mechanical strength is obtained. In addition, the dental mill blank obtained is suitably used in the fabrication of a dental prosthesis having high mechanical strength and excellent gloss retention, by machining a mill blank using a CAD/CAM system.