The present invention provides methods and compositions comprising compoundsuseful forstimulating neurogenesis and/or inhibiting neuronal degeneration, Thus, thepresent inventioncan be used in the treatment of diseases and conditions characterized byneuronal loss andreduced neurogenesis including Alzheimer's disease, stroke, traumatic braininjury, anddepression. This invention could also be used for research products includingsingle agents ormixtures of agents to promote, proliferate, differentiate, or maintain neuronsfrom stem orprogenitor cells. One compound according to the invention is:(see above formula)whereineach R1 is independently selected from the group consisting of H, F, Cl, Br,R7, and-O-R7, wherein R7 is a substituted 1-6 carbon alkyl or a 6-14 carbon aryl oraralkyl group；R2 is selected from O or S；R3 is (CH2)1m, wherein m is 1, 2 or 3；R4 is selected from the group consisting of an N and (CH n), wherein n equals1 or 2, withthe proviso that when R4 is nitrogen then m in R3 should not be equal to 1；R5 is a substituted heterocyclic aromatic group, except where R5 is 4-quinolinyl thesubstitution at the 2' position cannot be H or an amino group； andR6 is H.
