CALS, Joseph Maria Gerardus Barbara,NABUURS, Sander Bernardus
申请号：
ES14809794
公开号：
ES2722409T3
申请日:
2014.12.03
申请国别(地区):
ES
年份:
2019
代理人:
摘要：
A compound according to formula I ** (See formula) ** or a pharmaceutically acceptable salt thereof wherein A11-A14 are N or CR11, CR12, CR13, CR14, respectively, with the proviso that no more than two of the four positions A can be simultaneously N； R1 is C (1-6) alkyl, C (3-6) cycloalkyl, C (3-6) cycloalkyl (1-3) alkyl, (di) C (1-6) alkylamino, in where (di) C (1-6) alkylamino as used herein means an amino group, which is monosubstituted or independently substituted with H or C (1-6) alkyl group (s) and, when the groups (di) C (1-6) alkylamino contain two C (1-6) alkyl groups, one of the C (1-6) alkyl groups can be substituted with a C (3-6) cycloalkyl group, (di) C (3-6) cycloalkylamino wherein (di) C (3-6) cycloalkylamino as used herein means an amino group, which is monosubstituted or independently substituted with H or cycloalkylamino group (s) of C (3-6) and when the (di) cycloalkylamino groups of C (3-6) contain two cycloalkyl groups of C (3-6), one of the cycloalkyl groups of C (3-6) can be substituted by a C (1-6) alkyl group, or (di) (C (3-6) cycloalkyl C (1-3)) amino, wherein (di) (C (3 cycloalkyl) -6) C (1-3)) amino alkyl as used herein means an amino group, which is monosubstituted or independently substituted with H or C (3-6) cycloalkyl group (s) C (3-6) alkyl. 1-3), with all the carbon atoms of the alkyl groups optionally substituted with one or more F and all the carbon atoms of the cycloalkyl groups optionally substituted with one or more F or methyl； R2 and R3 are independently H, F, methyl, ethyl, hydroxy, methoxy or R2 and R3 together is carbonyl, all alkyl groups, if present, are optionally substituted with one or more F； R4 is H or C (1-6) alkyl； R5 is H, hydroxyethyl, methoxyethyl, C (1-6) alkyl, C (6-10) aryl, C (6-10) aryl (1-3) alkyl, C (1-9 heteroaryl) ), C (1-9) heteroaryl C (1-3) alkyl, C (3-6) cycloalkyl, C (3-6) cycloalkyl C (1-3) alkyl, C (2 heterocycloalkyl) -5) or C (2-5) heterocycloalkyl C (1-3) alkyl, all groups optionally subst
