ADAM MATTHEW GILBERT,ANTHONY P. RICKETTS,BRUCE KIPP ERICKSON,DAVID P. THOMPSON,EDMUND L. ELLSWORTH,EUGENE LVOVICH PIATNITSKI CHEKLER,JAMES THOMAS ANDERSON,PATRICK ROBERT VERHOEST,RAYOMAND JAL UNWALLA
申请号：
BR112015011897
公开号：
BR112015011897A2
申请日:
2013.11.25
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Abstract "New selective androgen receptor modulators" The present invention relates to a compound of formula 1, 2 or 3: wherein a is n or -cr0--, where r0 is hydrogen, C1-4 straight or branched chain alkyl. c6, etc., z is -cre- or -n-- where r is hydrogen, straight-chain or branched alkyl C1-c6, etc .； R1 is hydrogen, C1-6 straight or branched chain alkyl, etc .； R 2 is independently hydrogen or C 1 -C 6 straight or branched chain alkyl； R 3 and R 4 are independently hydrogen, C 1 -C 6 straight or branched chain alkyl, etc. R5 and R6 are independently hydrogen or C1-6 straight or branched chain alkyl, etc .； R 8 is hydrogen, C 1 -C 6 straight or branched chain alkyl, etc .； R 9 and R 10 are independently hydrogen or C 1 -C 6 straight or branched chain alkyl, etc .； q is --co--, - (ch2) q--, - (chrs) q-- or - (crsrt) q--, where rs and rt are independently C1- or straight-chain alkyl C 6, aryl, alkylaryl, heteroaryl or alkylheteroaryl； where q is 0, 1, 2 or 3； and where n is 0, 1, 2, 3, 4 or 5； or a pharmaceutically acceptable salt thereof, to compositions containing such compounds； and the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.resumo “novos moduladores seletivos do receptor de andrógeno” a presente invenção se refere a um composto da fórmula 1, 2 ou 3: em que a é n ou -cr0--, onde r0 é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc., z é -cre -- ou -n--, onde re é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc.； r1 é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc.； r2 é, independentemente, hidrogênio ou alquila de cadeia linear ou ramificada c1-c6； r3 e r4 são, independentemente, hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc；. r5 e r6 são, independentemente, hidrogênio ou alquila de cadeia linear ou ramificada c1-c6, etc； r8 é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc.； r9 e r10 são, independentement
