University of Southern California; LLC;S-Aima Holding Company, LLC;S-Aima Holding Company
发明人:
DESPANIE, Jordan Tremaine,GUO, Hao,MACKAY, John Andrew
申请号：
EP15867997
公开号：
EP3229845A4
申请日:
2015.12.10
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Described herein is the use of elastin-like polypeptides to generate hemoglobin-based oxygen carriers as a means of preventing and treating conditions caused by blood loss or anemia, for example, hemorrhagic shock. Elastin-like polypeptides are capable of creating therapeutically functional fusion proteins through genetic engineering with a therapeutic agent, for example, hemoglobin and biologic equivalent thereof. Specific forms of these fusion proteins have the ability to form into spherical nanoparticles possessing a therapeutically agent at their core. This provides a unique basis for employing elastin-like polypeptides as hemoglobin carriers in the manufacture of blood substitutes.
