Laurent MEIJER,Nassima OUMATA,Hervé GALONS,Aida GABDOULKHAKOVA,Vladimir RIAZANSKI,Deborah NELSON
申请号：
US14623799
公开号：
US20150320753A1
申请日:
2015.02.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method for treatment of disease by reduction in macrophages-mediated bacterial killing, including administration to patients in need a compound of formula (I):wherein A is N or CH； B is NO, or S； R1 is H, (C1-C4)alkyl group, methyl(C1-C6)cycloalkyl group or (C1-C6)cycloalkyl group； R2 is an aryl, arylmethyl group or methylheteroaryl group as methylpyridine and methylthiophene； R3 is absent when B is O or S, or is H or (C1-C4)alkyl group when B is N； R4 is (C1-C5)alkyl group or (C1-C4)cycloalkyl group, groups bearing a carboxylic acid group, and (C1-C5)alkyl group or (C1-C4)cycloalkyl substituted by hydroxyl group, halogen group or methoxy group, when B is N, R3 and R4 can together form a 5- or 6-membered heterocycle substituted by carboxylic acid group, substituted by a halogen atom, hydroxyl group, methoxy group or hydroxymethyl group, or pharmaceutically acceptable salt. Also provided are new compounds relating to this use.
