F. Gary Toback;Margaret M. Walsh-Reitz;Terence E. Martin
发明人:
F. Gary Toback,Terence E. Martin,Margaret M. Walsh-Reitz
申请号：
US13042958
公开号：
US08741838B2
申请日:
2011.03.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.
