#$%^&*AU2019232937A120191010.pdf#####H: dar [nerwvoven NRPortbl DCC DAR 16871920_.doex-26/04/2018 Abstract The present disclosure relates to a new pharmaceutical composition comprising Ceritinib. Particularly it is directed to the tablet that is prepared by wet granulation, wherein povidone is used as a binder. Further feature of the composition is that the drug and the binder form the inner phase, whereas all other excipients are added in a powder form as an outer phase. This way, the sticking of the composition is prevented and sufficient tablet hardness can be reached. Figure 1 LDK378 tablet 150MG - compression hardness profile 7060 -50 SExample3B -- Example4 I# 20_ _ -4- Example 5 -*-Example 6 10 20 5 10 15 20 25 30 Mean compression force [kN]
