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Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
专利权人:
Jian-Xin Li
发明人:
Jian-Xin Li,Brian Carlin,Thomas Ruszkay
申请号:
US11925235
公开号:
US08932629B2
申请日:
2007.10.26
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.
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