STEVENS SEAN,MURPHY ANDREW J.,HOSIAWA KAROLINA A.,MCWHIRTER JOHN,MACDONALD LYNN,DAVIS SAMUEL,BUCKLER DAVID R.
申请号：
NZ62058612
公开号：
NZ620586A
申请日:
2012.08.03
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a mouse comprising in its germline: (a) a humanised immunoglobulin heavy chain variable comprising at least one unrearranged human VH gene segment, at least one unrearranged human DH gene segment, and at least one unrearranged human JH gene segment operably linked to a heavy chain constant region gene； (b) a humanised immunoglobulin light chain locus comprising no more than one, or no more than two, rearranged human light chain V/J sequences operably linked to a light chain constant region gene； and, (c) an ectopic nucleic acid sequence encoding a mouse ADAM6 protein； or ortholog or homolog or functional fragment thereof, which is functional in a male mouse.
