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COMPOSITIONS AND METHODS OF IMMUNOTHERAPY
专利权人:
КОГНЕЙТ 3; ЛЛС (US)
发明人:
БРАУН Джо Эрнест (US)
申请号:
RU2010144744/15
公开号:
RU2010144744A
申请日:
2009.04.03
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of preventing or treating cell proliferation disorders in a mammalian subject, comprising administering to said subject a compound of formula I related to benzaldehyde or a benzaldehyde derivative, in an amount effective to suppress fermentation, or a pharmaceutically acceptable salt, isomer, enantiomer, solvate, hydrate thereof, precursor, polymorph or prodrug! ! where glucose is the α- or β-form of hexose selected from glucose, mannose, galactose, fructose, or a biose formed by two or more hexoses, wherein said hexoses may be the same or different. ! 2. The method according to claim 1, characterized in that the formula I is 4,6-O-benzylidine-D-glucopyranosyloxy. ! 3. The method according to claim 1, further comprising administering a secondary antiproliferative agent, or other additional therapeutic agent, effective in a combined composition or in an agreed treatment regimen with the specified compound of formula I, which is a benzaldehyde derivative, for the treatment or prevention of disorders associated with cell proliferation , the specified subject. ! 4. The method according to claim 3, characterized in that the secondary antiproliferative or additional therapeutic agent is administered to the specified subject in accordance with the agreed protocol of administration, simultaneously, before or after the introduction of the specified benzaldehyde derivative of the formula I to the specified subject. ! 5. The method according to claim 3, characterized in that the secondary antiproliferative or additional therapeutic agent is selected from the group consisting of: azacitidine, bevacizumab, bortezomib, capecitabine, cetuxi�1. Способ предотвращения или лечения нарушений пролиферации клеток у субъекта-млекопитающего, включающий введение указанному субъекту соединения формулы I, родственного бензальдегиду или являющегося производным бензальдегида, в количестве эффективном для подавления брожения, или его фармацевтически приемлемой соли, изомера, энантиом
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