The Board of Trustees of the Leland Stanford Junior University
发明人:
Neelima M Bhat,Marcia M. Bieber,Nelson N.H. Teng,Martin E. Sanders
申请号：
US13770619
公开号：
US20130164283A1
申请日:
2013.02.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.
