Nelson N. H. Teng;Neelima M. Bhat;Martin E. Sanders;Marcia M. Bieber
发明人:
Neelima M. Bhat,Marcia M. Bieber,Nelson N. H. Teng,Martin E. Sanders
申请号：
US11267935
公开号：
US08377435B2
申请日:
2005.11.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.
