A method for in vitro testing of an absorbent article includes the steps of inserting the absorbent article into a radiolucent simulated body cavity, placing the radiolucent simulated body cavity into a radiolucent pressure chamber, placing the radiolucent pressure chamber into a radiological device, pressurizing the radiolucent pressure chamber to a predetermined pressure, providing test liquid through the test liquid port and to the absorbent article, acquiring data relating to the absorbent article and the test liquid via the radiological device and an associated computing device, and analyzing the acquired data. The radiological pressure chamber includes a simulated body cavity arranged and configured to accommodate the absorbent article, a test liquid port, and a pressure control system. The radiolucent test device has at least one radio scanning element rotatable about radiolucent test device support having the pressure chamber disposed thereon.