AGENTS BLOQUANT LES CANAUX CALCIQUES DE TYPE T

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专利权人:

LTD.;NISSAN CHEMICAL INDUSTRIES

发明人:

MASUDA, YUKINORI,FURUKAWA, TAIJI

申请号：

CA2520628

公开号：

CA2520628C

申请日:

2004.03.29

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

There is provided a T-type calcium channel blocker that is optically active1,4-dihydropyridine compound, a pharmaceutically acceptable salt thereof or asolvatethereof, of formula (1)(see formula 1)wherein R1 and R2 are independently of each other C1-6alkyl group or R1 and R2together form -CR5R6-CR7R8-, -CR5R6-CR7R8-CR9R10- or -CR5R6-CR7R8-CR9R10-CR11R12-, etc., X1 and X2 are independently of each other O or NR13, Ar isoptionallysubstituted phenyl group, etc., R a and R b are independently of each other C1-6 alkylgroup, -L2-NR16R17, CH2O-L2-NR16R17, CN, -L2-N(CH2CH2)2NR16 or NR16R17, etc.,Y isC1-20 alkyl group, -L3-NR18R19(see formula 2), (see formula 3)(see formula 4), (see formula 5) or (see formula 6)and * is absolute configuration of R.

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