The present invention relates to a hypoallergenic molecule derived from Phl p 5 and consisting of 15 to 40 amino acids, wherein said molecule comprises amino acids 26 to 58, 176 to 212, 217 to 246, 93 to 128, 98 to 128, 26 to 53, 252 to 283 or 132 to 162 of Phl p 5 or a variant of these fragments truncated by 1 to 5 amino acid residues.