A compound represented by the following generalformula (I) or a pharmacologically acceptable saltthereof, wherein R1 represents a C1 to C6 alkyl groupwhich may be substituted by one to three groups selectedfrom substituent group A, or the like (substituent groupA: a hydroxy group, a halogeno group, a cyano group, anitro group, an amino group, a carboxy group, a C1 to C3alkyl group, etc.)； R2, R3, and R8 each independentlyrepresent a hydrogen atom or a C1 to C3 alkyl group； R4,R5, R6, R7, R9, and R10 each independently represent ahydrogen atom or the like； and R11 represents a hydrogenatom or the like, has TAFIa enzyme inhibitory activityand is useful as a therapeutic drug for myocardialinfarction, angina pectoris, acute coronary syndrome,cerebral infarction, deep vein thrombosis, pulmonaryembolism, or the like.
