A compound represented by the following generalformula (I) or a pharmacologically acceptable saltthereof, wherein A represents a C3 to C12 cycloalkylgroup which may be substituted by one to three selectedfrom a fluoro group, a hydroxy group, a C1 to C6 alkylgroup, etc； R1, R2, and R3 each independently represent ahydrogen atom, a fluoro group, or a C1 to C6 alkyl group；R4 represents a hydrogen atom or a prodrug group； and Yrepresents -CH2-CHR5-CH2-NHR6 (wherein R5 represents ahydrogen atom, a C1 to C6 alkyl group, or a C1 to C6alkoxy group, and R6 represents a hydrogen atom or aprodrug group), or the like exhibits excellent TAFIainhibitory activity and is useful as a therapeutic drugfor myocardial infarction, angina pectoris, acutecoronary syndrome, cerebral infarction, deep veinthrombosis, pulmonary embolism, and the like.
