An objective of this invention is to provide a novel measuring or evaluating method capable of easily and accurately measuring or evaluation skin texture state by using an biochemical index, rather than surgically removing skin to thereby stimulate skin. An evaluating method for skin texture of this invention uses expression amount of interleukin-1 receptor antagonist in skin horny layer as an index.本發明的課題係提供不是以外科方式摘取皮膚而對皮膚帶來刺激等的方法，而是可簡便且確實地測定或評價肌理狀態的使用生物化學指標的新穎的測定或評價方法。本發明的皮膚肌理的評價方法，係以皮膚角質層中的白細胞介素-1受體拮抗劑的表現量作為指標。
