Lactobacillus plantarum KC3 the composition comprising Lactobacillus plantarum KC3 as an active ingredient for preventing or treating immune disorders respiratory inflammation disease allergy or asthma and the use thereof
The present invention relates to a composition for improving or preventing immune disorders and preventing or treating respiratory inflammatory diseases containing Lactobacillus plantarum KC3 new lactic acid bacteria (also referred to as “CKDB-KC3”) as an active ingredient. The novel strain according to the present invention is a characteristic experiment of Lactobacillus plantarum KC3 new lactic acid bacteria (Experimental Example 1)； Inhibitory effect of probiotics on the expression of inflammatory cytokines in the intestine (Experimental Example 2)； Anti-inflammatory inhibitory effect test for edema (Experimental Example 3)； Through animal tests, such as a protective effect against respiratory damage caused by air pollutants such as fine dust (Experimental Example 4), it was confirmed that the Lactobacillus plantarum KC3 strain exhibits excellent immune disorder improvement and respiratory respiratory disease suppression activity, Confirmed that the composition is useful as a pharmaceutical composition or health functional food for improving and preventing immune disorders and respiratory inflammatory diseases, useful as a pharmaceutical composition, health functional food or health supplement for improving immune disorders and preventing or treating respiratory inflammatory diseases Do.본 발명은 락토바실러스 플란타룸 KC3 신규 유산균(“CKDB-KC3”로도 지칭)을 유효성분으로 함유하는 면역장애 개선 및 호흡기염증질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 신규 균주는 락토바실러스 플란타룸 KC3 신규 유산균의 특성 실험(실험예 1)； 프로바이오틱스의 장내 염증성 사이토카인의 발현 억제 효과(실험예 2)； 귀부종에 대한 항염증 억제 효과 시험(실험예 3)； 미세먼지 등 대기오염물질에 의한 호흡기 손상에 대한 방어 효과(실험예 4) 등의 동물실험을 통하여 락토바실러스 플란타룸 KC3 균주가 탁월한 면역장애 개선 및 호흡기염증질환 억제 활성을 나타냄을 확인하여, 상기 조성물을 면역장애 개선 및 호흡기염증질환의 예방 및 치료용 약학조성물 또는 건강기능식품으로 유용함을 확인하여, 면역장애 개선 및 호흡기염증질환의 예방 또는 치료용 약학조성물, 건강기능식품 또는 건강보조식품으로 유용하다.
