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HUMANIZED ANTIBODIES THAT RECOGNIZE ALPHA-SINUCLEIN
专利权人:
ПРОТЕНА БИОСАЙЕНСИС ЛИМИТЕД (IE)
发明人:
САЛДАНХА Хосе (GB),НИЙДЖАР Тарлочан С. (US)
申请号:
RU2014121325/10
公开号:
RU2014121325A
申请日:
2012.10.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An antibody that binds to alpha synuclein containing a mature variable region of the heavy chain having the amino acid sequence of SEQ ID NO: 11, and a mature variable region of the light chain having the amino acid sequence of SEQ ID NO: 4, except when the position L36 (Kabat numbering) may be occupied Υ or F, position L83 (Kabat numbering) may be occupied F or L, position H73 (Kabat numbering) may be occupied N or D and position H93 (Kabat numbering) may be occupied A or S.2. The antibody of claim 1, wherein the mature variable region of the heavy chain has the amino acid sequence indicated by SEQ ID NO: 10.3. The antibody of claim 1, wherein the mature variable region of the light chain has an amino acid sequence designated SEQ ID NO: 5.4. The antibody of claim 1, wherein position H73 (Kabat numbering) is occupied by D and position H93 (Kabat numbering) is occupied by A.5. The antibody of claim 1, wherein the mature variable region of the light chain has the amino acid sequence of SEQ ID NO: 3, 4, or 5, and the mature variable region of the heavy chain has the amino acid sequence of SEQ IDNO: 8, 9, or 10.6. The antibody according to claim 5, containing a constant region of the heavy chain having the amino acid sequence of SEQ ID NO: 32.7. The antibody according to claim 5, containing a constant region of the light chain having the amino acid sequence of SEQ ID NO: 13.8. An antibody that binds to an alpha synuclein containing a humanized heavy chain containing three Kabat CDRs of SEQ ID NO: 11 and a humanized light chain containing three CDRs of Kabat SEQ ID NO: 4, provided that the position is L36 (numbering by Kabat) occupied by F, and / or position L83 (Kabat numbering) occupied by L, and / or position H73 (�1. Антитело, которое связывается с альфа-синуклеином, содержащее зрелую вариабельную область тяжелой цепи, имеющую аминокислотную последовательность SEQ ID NO:11, и зрелую вариабельную область легкой цепи, имеющую аминокислотную последовательность SEQ ID
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