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ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ПЕРОРАЛЬНОГО ВВЕДЕНИЯ, СОДЕРЖАЩАЯ СТАТИН
专利权人:
ХЕКСАЛ АГ
发明人:
ТЮБРИХ Тереза,РОТЕР Патрик
申请号:
RU2014105690
公开号:
RU2014105690A
申请日:
2012.08.21
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A pharmaceutical composition for oral administration comprising or consisting of: (i) from 10 to 30% by weight of at least one pharmaceutically active agent selected from the group consisting of water-soluble statins prone to oxidative degradation, preferably of atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, or combinations thereof, (ii) from 0.01 to 3% by weight of the first agent (A1) with antioxidant activity, (iii) from 0.01 to 3% by weight of the second material (A2) with antioxidant activity, different from the first agent (A1) with antioxidant activity, (iv) from 60 to 85% by weight of at least one additive selected from the group consisting of a filler, binder, agents for flowability regulation disintegrant and an agent that prevents adhesion or kombinatsiy.2. A pharmaceutical composition according to claim. 1, characterized in that the content of at least one pharmaceutically active substance is from 11 to 25% by weight, preferably 12.5 to 20% by masse.3. A pharmaceutical composition according to Claim. 1 or 2, wherein the content of the first agent (A1) with the antioxidant is 0.01 to 2.5% by weight, preferably from 0.01 to 1% by weight or 0.01 to 0.05% by masse.4. A pharmaceutical composition according to any one of claims. 1 or 2, wherein the content of the second agent (A2) with antioxidant activity from 0.01 to 2.5% by weight, preferably from 0.01 to 1% by weight or from 0.01 to 0.05% by masse.5. A pharmaceutical composition according to any one of claims. 1 or 2, characterized in that the pharmaceutically active substance is simvast1. Фармацевтическая композиция для перорального введения, содержащая или состоящая из:(i) от 10 до 30% по массе по меньшей мере одного фармацевтически активного вещества, выбранного из группы, состоящей из растворимых в воде подверженных окислительному разложению статинов, предпочтительно аторвастатина, церивастатина, флувастатина, ловастатина, питавастатина, пр
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