A stent delivery system includes an inner shaft having a proximal portion and a distal portion, and a radially expandable prosthesis disposed over the inner shaft. The prosthesis has a radially collapsed configuration and a radially expanded configuration, wherein in the collapsed configuration the prosthesis is adapted to be delivered through a vasculature, and in the expanded configuration the prosthesis engages a vessel wall. The stent delivery system also includes an outer shaft having a proximal portion and a distal portion, a shuttle sheath disposed over the radially expandable prosthesis and configured to be in a pre-set locked position with respect to the inner shaft and the outer shaft to operate in a reverse deployment direction.